We investigate the hot cracking susceptibility and creep resistance of three versions of a nickel-based superalloy with different contents of boron, carbon and zirconium fabricated by laser powder bed fusion. Crack-free and creep resistant components are achieved for alloys with boron, carbon and no zirconium. We then rationalize this result by evaluating how boron, carbon and zirconium are distributed at grain boundaries in the as-built and heat-treated microstructures of an alloy containing all these elements. Observations are conducted by scanning and transmission electron microscopy, and atom probe tomography. In the as-built microstructure, boron, carbon and zirconium segregate at high-angle grain boundaries as a result of solute partitioning to the liquid and limited solid-state diffusion during solidification and cooling. After heat-treatment, the amount of boron and carbon segregating at grain boundaries increases significantly. In contrast, zirconium is not found at grain boundaries but it partitions at the gamma' precipitates formed during the heat treatment. The presence of zirconium at grain boundaries in the as-built condition is known to be susceptible to enhance hot cracking, while its absence in the heat-treated microstructure strongly suggests that this element has no major effect on the creep resistance. Based on our observations, we propose alloy design guidelines to at the same time avoid hot cracking during fabrication and achieve the required creep performance after heat-treatment.