Vesicles and many biological membranes are made of two monolayers of lipid molecules and form closed lipid bilayers. The dynamical behaviour of vesicles is very complex and a variety of forms and shapes appear. Lipid bilayers can be considered as a surface fluid and hence the governing equations for the evolution include the surface (Navier--)Stokes equations, which in particular take the membrane viscosity into account. The evolution is driven by forces stemming from the curvature elasticity of the membrane. In addition, the surface fluid equations are coupled to bulk (Navier--)Stokes equations. We introduce a parametric finite element method to solve this complex free boundary problem, and present the first three dimensional numerical computations based on the full (Navier--)Stokes system for several different scenarios. For example, the effects of the membrane viscosity, spontaneous curvature and area difference elasticity (ADE) are studied. In particular, it turns out, that even in the case of no viscosity contrast between the bulk fluids, the tank treading to tumbling transition can be obtained by increasing the membrane viscosity. Besides the classical tank treading and tumbling motions, another mode (called the transition mode in this paper, but originally called the vacillating-breathing mode and subsequently also called trembling, transition and swinging mode) separating these classical modes appears and is studied by us numerically. We also study how features of equilibrium shapes in the ADE and spontaneous curvature models, like budding behaviour or starfish forms, behave in a shear flow.

The non-first-order-factorizable contributions (The terms 'first-order-factorizable contributions' and 'non-first-order-factorizable contributions' have been introduced and discussed in Refs. \cite{Behring:2023rlq,Ablinger:2023ahe}. They describe the factorization behaviour of the difference- or differential equations for a subset of master integrals of a given problem.) to the unpolarized and polarized massive operator matrix elements to three-loop order, $A_{Qg}^{(3)}$ and $\Delta A_{Qg}^{(3)}$, are calculated in the single-mass case. For the $_2F_1$-related master integrals of the problem, we use a semi-analytic method based on series expansions and utilize the first-order differential equations for the master integrals which does not need a special basis of the master integrals. Due to the singularity structure of this basis a part of the integrals has to be computed to $O(\varepsilon^5)$ in the dimensional parameter. The solutions have to be matched at a series of thresholds and pseudo-thresholds in the region of the Bjorken variable $x \in ]0,\infty[$ using highly precise series expansions to obtain the imaginary part of the physical amplitude for $x \in ]0,1]$ at a high relative accuracy. We compare the present results both with previous analytic results, the results for fixed Mellin moments, and a prediction in the small-$x$ region. We also derive expansions in the region of small and large values of $x$. With this paper, all three-loop single-mass unpolarized and polarized operator matrix elements are calculated.