Gandhi Institute of Technology and Management
Liquid-liquid phase separation (LLPS) involving intrinsically disordered protein regions (IDRs) is a major physical mechanism for biological membraneless compartmentalization. The multifaceted electrostatic effects in these biomolecular condensates are exemplified here by experimental and theoretical investigations of the different salt- and ATP-dependent LLPSs of an IDR of messenger RNA-regulating protein Caprin1 and its phosphorylated variant pY-Caprin1, exhibiting, e.g., reentrant behaviors in some instances but not others. Experimental data are rationalized by physical modeling using analytical theory, molecular dynamics, and polymer field-theoretic simulations, indicating that interchain ion bridges enhance LLPS of polyelectrolytes such as Caprin1 and the high valency of ATP-magnesium is a significant factor for its colocalization with the condensed phases, as similar trends are observed for other IDRs. The electrostatic nature of these features complements ATP's involvement in π\pi-related interactions and as an amphiphilic hydrotrope, underscoring a general role of biomolecular condensates in modulating ion concentrations and its functional ramifications.
We prove that for finitely generated free semigroup actions the average shadowing property, the weak asymptotic average shadowing property, the mean ergodic shadowing property, the almost asymptotic average shadowing property, the asymptotic average shadowing property and the MαM_{\alpha}-shadowing property for every α(0,1)\alpha\in (0,1), are equivalent. This gives an affirmative answer to an open question asked in Question 10.3 [M. Kulczycki, D. Kwietniak, P. Oprocha, On almost specification and average shadowing properties, Fundamenta Mathematicae, 224 (2014)].
Achieving perfect control over the parameters defining a quantum gate is, in general, a very challenging task, and at the same time, environmental interactions can introduce disturbances to the initial states as well. Here we address the problem of how the imperfections in unitaries and noise present in the input states affect the entanglement-generating power of a given quantum gate -- we refer to it as imperfect (noisy) entangling power. We observe that, when the parameters of a given unitary are chosen randomly from a Gaussian distribution centered around the desired mean, the quenched average entangling power -- averaged across multiple random samplings -- exhibits intriguing behavior like it may increase or show nonmonotonic behavior with the increase of disorder strength for certain classes of diagonal unitary operators. For arbitrary unitary operators, the quenched average power tends to stabilize, showing almost constant behavior with variation in the parameters instead of oscillating. Our observations also reveal that, in the presence of a local noise model, the input states that maximize the entangling power of a given unitary operator differ considerably from the noiseless scenario. Additionally, we report that the rankings among unitary operators according to their entangling power in the noiseless case change depending on the noise model and noise strength.
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