Since the launch of JWST, the sample size of reionization-era Lyman-alpha-emitters (LAEs) has been steadily growing; yet inferences about the neutral hydrogen fraction in the intergalactic medium exhibit increasing variance at redshift z ~ 7, possibly indicating significant field-to-field fluctuations in the progression of cosmic reionization. In this paper, we present new JWST/NIRSpec and Keck/LRIS spectra of nine LAEs in the redshift z ~ 7 protocluster, LAGER-z7OD1. Measurements of Lyman-alpha-transmission and Lyman-alpha velocity offset along multiple sightlines map the Lyman-alpha damping wing optical depth across the galaxy overdensity. In the standard context of inside-out ionization, we estimate radii of ionized bubbles (R(min) = 0.07 - 0.69 Mpc) based on the distance from each LAE to the first neutral patch along the sightline. The resulting 3D topology reveals three distinct sub-clusters where the ionized bubbles are approaching overlap. Five of the nine LAEs plausibly ionized their bubbles, a few bursts of star formation and a modest escape fraction are sufficient. We demonstrate, however, that the actual ionized volumes are likely larger, at least R(ism) = 0.42 - 1.29 Mpc, based on an empirical model for interstellar attenuation of Lyman-alpha. Modeling galactic attenuation of Lyman-alpha significantly increases the inferred intergalactic transmission (thus enlarging the ionized pathlength). The errorbars on the reddening correction allow fully overlapping bubbles, and our results are consistent with accelerated reionization in the protocluster.

We extend the Sonora Diamondback brown dwarf evolution models to higher effective temperatures to treat the evolution of younger, higher mass objects. Due to an upper temperature limit of $T_\mathrm{eff}=$2400 K in the original Sonora Diamondback model grid, high mass objects ($M\geq$ 0.05 $M_\mathrm{\odot}=$ 52.4 $M_\mathrm{J}$) were limited to ages of $\gtrsim$ 100 Myr. To include the early evolution of brown dwarfs at T_\mathrm{eff}> 2400 K, we use existing and new SPHINX cloud-free model atmosphere calculations of temperature structures of M-type atmospheres. These atmospheres range from $T_\mathrm{eff}$ 2000--4000 K, log($g$) 3.0--5.5, and metallicity [M/H] $-$0.5 to $+$0.5. This combination of Diamondback and SPHINX atmospheres, with a transition across $T_\mathrm{eff}$ 2000--2400 K, allows us to calculate evolution tracks, and infrared photometry and colors, for ages > 1 Myr and masses from above the hydrogen burning minimum mass down to planetary masses. The Hayashi phase of massive brown dwarf evolution (ages < 10--100 Myr) at low surface gravity leads to nearly constant $T_\mathrm{eff}$ values, at effective temperatures much lower than would be obtained from simply extrapolating backwards from evolution tracks at older ages.

This report describes the 2014 study by the Science Definition Team (SDT) of the Wide-Field Infrared Survey Telescope (WFIRST) mission. It is a space observatory that will address the most compelling scientific problems in dark energy, exoplanets and general astrophysics using a 2.4-m telescope with a wide-field infrared instrument and an optical coronagraph. The Astro2010 Decadal Survey recommended a Wide Field Infrared Survey Telescope as its top priority for a new large space mission. As conceived by the decadal survey, WFIRST would carry out a dark energy science program, a microlensing program to determine the demographics of exoplanets, and a general observing program utilizing its ultra wide field. In October 2012, NASA chartered a Science Definition Team (SDT) to produce, in collaboration with the WFIRST Study Office at GSFC and the Program Office at JPL, a Design Reference Mission (DRM) for an implementation of WFIRST using one of the 2.4-m, Hubble-quality telescope assemblies recently made available to NASA. This DRM builds on the work of the earlier WFIRST SDT, reported by Green et al. (2012) and the previous WFIRST-2.4 DRM, reported by Spergel et. (2013). The 2.4-m primary mirror enables a mission with greater sensitivity and higher angular resolution than the 1.3-m and 1.1-m designs considered previously, increasing both the science return of the primary surveys and the capabilities of WFIRST as a Guest Observer facility. The addition of an on-axis coronagraphic instrument to the baseline design enables imaging and spectroscopic studies of planets around nearby stars.

The Gamow Explorer will use Gamma Ray Bursts (GRBs) to: 1) probe the high redshift universe (z > 6) when the first stars were born, galaxies formed and Hydrogen was reionized; and 2) enable multi-messenger astrophysics by rapidly identifying Electro-Magnetic (IR/Optical/X-ray) counterparts to Gravitational Wave (GW) events. GRBs have been detected out to z ~ 9 and their afterglows are a bright beacon lasting a few days that can be used to observe the spectral fingerprints of the host galaxy and intergalactic medium to map the period of reionization and early metal enrichment. Gamow Explorer is optimized to quickly identify high-z events to trigger follow-up observations with JWST and large ground-based telescopes. A wide field of view Lobster Eye X-ray Telescope (LEXT) will search for GRBs and locate them with arc-minute precision. When a GRB is detected, the rapidly slewing spacecraft will point the 5 photometric channel Photo-z Infra-Red Telescope (PIRT) to identify high redshift (z > 6) long GRBs within 100s and send an alert within 1000s of the GRB trigger. An L2 orbit provides > 95% observing efficiency with pointing optimized for follow up by the James Webb Space Telescope (JWST) and ground observatories. The predicted Gamow Explorer high-z rate is >10 times that of the Neil Gehrels Swift Observatory. The instrument and mission capabilities also enable rapid identification of short GRBs and their afterglows associated with GW events. The Gamow Explorer will be proposed to the 2021 NASA MIDEX call and if approved, launched in 2028.

We have studied the relationship between the star formation rate (SFR) surface density and gas surface density in the spiral galaxy M51a (NGC 5194), using multi-wavelength data obtained as part of the Spitzer Infrared Nearby Galaxies Survey (SINGS). We introduce a new SFR index based on a linear combination of H-alpha emission-line and 24 micron continuum luminosities, that provides reliable extinction-corrected ionizing fluxes and SFR densities over a wide range of dust attenuations. The combination of these extinction-corrected SFR densities with aperture synthesis HI and CO maps has allowed us to probe the form of the spatially-resolved star formation law on scales of 0.5 to 2 kpc. We find that the resolved SFR vs gas surface density relation is well represented by a Schmidt power law, which is similar in form and dispersion to the disk-averaged Schmidt law. We observe a comparably strong correlation of the SFR surface density with the molecular gas surface density, but no significant correlation with the surface density of atomic gas. The best-fitting slope of the Schmidt law varies from N = 1.37 to 1.56, with zeropoint and slope that change systematically with the spatial sampling scale. We tentatively attribute these variations to the effects of areal sampling and averaging of a nonlinear intrinsic star formation law. Our data can also be fitted by an alternative parametrization of the SFR surface density in terms of the ratio of gas surface density to local dynamical time, but with a considerable dispersion.

Though type-Ia supernovae (SNe Ia) are found in all types of galaxies, recent local Hubble constant measurements have disfavored using SNe Ia in early-type or quiescent galaxies, aiming instead for better consistency with SNe Ia in star-forming, late-type host galaxies calibrated by Cepheid distances. Here we investigate the feasibility of a parallel distance ladder using SNe Ia exclusively in quiescent, massive ($\log M_*/M_{\odot} \geq 10$) host galaxies, calibrated by tip of the red giant branch (TRGB) distances. We present TRGB measurements to four galaxies: three measured from the Hubble Space Telescope with the ACS F814W filter, and one measured from the JWST NIRCam F090W filter. Combined with literature measurements, we define a TRGB calibrator sample of five high-mass, early-type galaxies that hosted well-measured SNe Ia: NGC 1316 (SN 2006dd), NGC 1380 (SN 1992A), NGC 1404 (SN 2007on, SN 2011iv), NGC 4457 (SN 2020nvb), and NGC 4636 (SN 2020ue). We jointly standardize these calibrators with a fiducial sample of 124 Hubble-flow SNe Ia from the Zwicky Transient Facility that are matched in host-galaxy and light-curve properties. Our results with this homogenized subsample show a Hubble residual scatter of under 0.11 mag, lower than usually observed in cosmological samples of the full SN~Ia distribution. We obtain a measurement of the Hubble constant, $H_0 = 75.3 \pm 2.9$ km s$^{-1}$ Mpc$^{-1}$, including statistical and estimated systematic uncertainties, and discuss the potential to further improve the precision of this approach. As calibrator and supernova samples grow, we advocate that future cosmological applications of SNe Ia use subsamples matched in host-galaxy and supernova properties across redshift.

We describe the physical characteristics of interstellar comet 3I/ATLAS, discovered on 2025 July 1 by the Asteroid Terrestrial-impact Last Alert System. The comet has eccentricity, $e$ $\simeq$ 6.08 and velocity at infinity, v$_{\infty}$ $\simeq$ 57 km/s, indicating an interstellar origin. \textbf{We obtained B,V, R, I, g, r, i, and z photometry with the Kottamia Astronomical Observatory 1.88-m telescope, the Palomar 200-inch telescope, and the Astrophysical Research Consortium 3.5-m telescope on 2025 July 2, 3, and 6. We measured colour indices B-V=0.98$\pm$0.23, V-R=0.71$\pm$0.09, R-I=0.14$\pm$0.10, g-r=0.84$\pm$0.05 mag, r-i=0.16$\pm$0.03 mag, i-z=-0.02$\pm$0.07 mag, and g-i=1.00$\pm$0.05 mag and a spectral slope of 16.0$\pm$1.9 $\%$/100 nm.} We calculate the dust cross-section within 10,000 km of the comet to be 184.6$\pm$4.6 km$^2$, assuming an albedo of 0.10. 3I/ATLAS's coma has FWHM$\simeq$2.2 arcsec and A(0$^\circ$)f$\rho$=280.8$\pm$3.2 cm. \textbf{We estimate that 3I/ATLAS's \textmu m-scale to mm-scale dust is ejected at $\sim$0.01-1 m/s, implying a dust production of $\sim$0.1 - 1.0 kg/s.

A new class of radio source, the so-called Odd Radio Circles (ORCs), have been discovered by recent sensitive, large-area radio continuum surveys. The distances of these sources have so far relied on photometric redshifts of optical galaxies found at the centers of or near the ORCs. Here we present Gemini rest-frame optical spectroscopy of six galaxies at the centers of, or potentially associated with, the first five ORC discoveries. We supplement this with Legacy Survey imaging and Prospector fits to their griz+W1/W2 photometry. Of the three ORCs with central galaxies, all lie at distances (z = 0.27-0.55) that confirm the large intrinsic diameters of the radio circles (300-500 kpc). The central galaxies are massive ($M_*\sim10^{11}M_\odot$), red, unobscured ellipticals with old ($\gtrsim$1~Gyr) stellar populations. They have LINER spectral types that are shock- or AGN-powered. All three host low-luminosity, radio-quiet AGN. The similarity of their central galaxies are consistent with a common origin, perhaps as a blastwave from an ancient starburst. The other two ORCs are adjacent and have no prominent central galaxies. However, the z=0.25 disk galaxy that lies between them hosts a Type 2, moderate-luminosity AGN. They may instead be the lobes of a radio jet from this AGN.

Ring systems have recently been discovered around several small bodies in the outer Solar System through stellar occultations. While such measurements provide key information on ring geometry and dynamical interactions, little is known about their composition, grain size distribution, origin, lifetime, or evolutionary pathways. Here we report near-infrared observations from the James Webb Space Telescope (JWST) of a stellar occultation by the Centaur (10199) Chariklo, providing unprecedented constraints on the material properties of a small-body ring system and offering insights into their origin and evolution. These measurements reveal that Chariklo's inner dense ring contains predominantly micrometer-sized particles and exhibits a significant increase in opacity compared to previous observations, suggesting active replenishment events. Most strikingly, the outer ring shows a much weaker near-infrared occultation signature than in earlier visible-light detections. This discrepancy may indicate ongoing material loss, implying that the outer ring is transient, or it may reflect wavelength-dependent opacity consistent with a dusty structure dominated by $0.2$-$0.5$ $\mu$m silicate grains. These scenarios, not mutually exclusive, point to an unprecedented level of complexity in small-body ring systems, unlike anything observed around other minor bodies in the Solar System.

We use \Pab\ (1282~nm) observations from the Hubble Space Telescope ($\HST$) G141 grism to study the star-formation and dust attenuation properties of a sample of 29 low-redshift (z < 0.287) galaxies in the CANDELS Ly$\alpha$ Emission at Reionization (CLEAR) survey. We first compare the nebular attenuation from $\Pab/\Ha$ with the stellar attenuation inferred from the spectral energy distribution, finding that the galaxies in our sample are consistent with an average ratio of the continuum attenuation to the nebular gas of 0.44, but with a large amount of excess scatter beyond the observational uncertainties. Much of this scatter is linked to a large variation between the nebular dust attenuation as measured by (space-based) $\Pab$ to (ground-based) $\Ha$ to that from (ground-based) $\Ha/\Hb$. This implies there are important differences between attenuation measured from grism-based / wide-aperture $\Pab$ fluxes and the ground-based / slit-measured Balmer decrement. We next compare star-formation rates (SFRs) from $\Pab$ to those from dust-corrected UV. We perform a survival analysis to infer a census of \Pab\ emission implied by both detections and non-detections. We find evidence that galaxies with lower stellar mass have more scatter in their ratio of \Pab\ to attenuation-corrected UV SFRs. When considering our \Pab\ detection limits, this observation supports the idea that lower mass galaxies experience "burstier" star-formation histories. Together, these results show that \Pab\ is a valuable tracer of a galaxy's SFR, probing different timescales of star-formation and potentially revealing star-formation that is otherwise missed by UV and optical tracers.

The Cosmology Large Angular Scale Surveyor (CLASS) is a four-telescope array observing the largest angular scales ($2 \lesssim \ell \lesssim 200$) of the cosmic microwave background (CMB) polarization. These scales encode information about reionization and inflation during the early universe. The instrument stability necessary to observe these angular scales from the ground is achieved through the use of a variable-delay polarization modulator (VPM) as the first optical element in each of the CLASS telescopes. Here we develop a demodulation scheme used to extract the polarization timestreams from the CLASS data and apply this method to selected data from the first two years of observations by the 40 GHz CLASS telescope. These timestreams are used to measure the $1/f$ noise and temperature-to-polarization ($T\rightarrow P$) leakage present in the CLASS data. We find a median knee frequency for the pair-differenced demodulated linear polarization of 15.12 mHz and a $T\rightarrow P$ leakage of <3.8\times10^{-4} (95\% confidence) across the focal plane. We examine the sources of $1/f$ noise present in the data and find the component of $1/f$ due to atmospheric precipitable water vapor (PWV) has an amplitude of $203 \pm 12 \mathrm{\mu K_{RJ}\sqrt{s}}$ for 1 mm of PWV when evaluated at 10 mHz; accounting for $\sim32\%$ of the $1/f$ noise in the central pixels of the focal plane. The low level of $T\rightarrow P$ leakage and $1/f$ noise achieved through the use of a front-end polarization modulator enables the observation of the largest scales of the CMB polarization from the ground by the CLASS telescopes.

Long-term high-cadence measurements of stellar spectral variability are fundamental to better understand stellar atmospheric properties and stellar magnetism. These, in turn, are fundamental for the detectability of exoplanets as well as the characterization of their atmospheres and habitability. The Sun, viewed as a star via disk-integrated observations, offers a means of exploring such measurements while also offering the spatially resolved observations that are necessary to discern the causes of observed spectral variations. High-spectral resolution observations of the solar spectrum are fundamental for a variety of Earth-system studies, including climate influences, renewable energies, and biology. The Integrated Sunlight Spectrometer at SOLIS, has been acquiring daily high-spectral resolution Sun-as-a-star measurements since 2006.More recently, a few ground-based telescopes with the capability of monitoring the solar visible spectrum at high spectral resolution have been deployed (e.g. PEPSI, HARPS, NEID). However, the main scientific goal of these instruments is to detect exo-planets, and solar observations are acquired mainly as a reference. Consequently, their technical requirements are not ideal to monitor solar variations with high photometric stability, especially over solar-cycle temporal scales.The goal of this white paper is to emphasize the scientific return and explore the technical requirements of a network of ground-based spectrographs devoted to long-term monitoring of disk-integrated solar-spectral variability with high spectral resolution and high photometric stability, in conjunction with disk-resolved observations in selected spectral lines,to complement planet-hunter measurements and stellar-variability studies. The proposed network of instruments offers the opportunity for a larger variety of multidisciplinary studies.

The Fermi Gamma-ray Burst Monitor (GBM) is currently the most prolific detector of Gamma-Ray Bursts (GRBs). Recently the detection rate of short GRBs (SGRBs) has been dramatically increased through the use of ground-based searches that analyze GBM continuous time tagged event (CTTE) data. Here we examine the efficiency of a method developed to search CTTE data for sub-threshold transient events in temporal coincidence with LIGO/Virgo compact binary coalescence triggers. This targeted search operates by coherently combining data from all 14 GBM detectors by taking into account the complex spatial and energy dependent response of each detector. We use the method to examine a sample of SGRBs that were independently detected by the Burst Alert Telescope on board the Neil Gehrels Swift Observatory, but which were too intrinsically weak or viewed with unfavorable instrument geometry to initiate an on-board trigger of GBM. We find that the search can successfully recover a majority of the BAT detected sample in the CTTE data. We show that the targeted search of CTTE data will be crucial in increasing the GBM sensitivity, and hence the gamma-ray horizon, to weak events such as GRB 170817A. We also examine the properties of the GBM signal possibly associated with the LIGO detection of GW150914 and show that it is consistent with the observed properties of other sub-threshold SGRBs in our sample. We find that the targeted search is capable of recovering true astrophysical signals as weak as the signal associated with GW150914 in the untriggered data.

Transiting exoplanet atmospheric characterization is currently in a golden age as dozens of exoplanet atmospheres are being studied by NASA's Hubble and James Webb Space Telescopes. This trend is expected to continue with NASA's Pandora Smallsat and Roman Space Telescope and ESA's Ariel mission (all expected to launch within this decade) and NASA's Habitable Worlds Observatory (expected to launch in the early 2040s) all of which are centered around studying the atmospheres of exoplanets. Here we explore a new approach to constructing large scale exoatmospheric survey lists, which combines the use of traditional transmission/emission spectroscopy figures of merit with a focus on more-evenly sampling planets across a range of radii and equilibrium temperatures. After assembling a sample target list comprised of 750 transmission spectroscopy targets and 150 emission spectroscopy targets, we quantify the potential time lost to stale transit and eclipse ephemerides and find that hundreds of hours of space-based observing could be wasted given current uncertainties in orbital periods, transit epochs, and orbital eccentricities. We further estimate the amount of ground-based telescope time necessary to obtain sufficiently precise exoplanet masses and find that it exceeds 100 nights of 10m telescope time. Based upon these findings, we provide a list of recommendations that would make community efforts for preparation and interpretation of atmospheric characterization endeavors more effective and efficient. The strategies we recommend here can be used to support both current (e.g., HST and JWST) and future exoplanet atmosphere characterization missions (e.g., Pandora, Ariel, Roman, and the Habitable Worlds Observatory).

We present near-infrared and optical emission-line and stellar kinematics of the Seyfert 2 galaxy Mrk 573 using the Near-Infrared Field Spectrograph (NIFS) at Gemini North and Dual Imaging Spectrograph (DIS) at Apache Point Observatory, respectively. By obtaining full kinematic maps of the infrared ionized and molecular gas and stellar kinematics in a 700 x 2100 pc^2 circumnuclear region of Mrk 573, we find that kinematics within the Narrow-Line Region (NLR) are largely due to a combination of both rotation and in situ acceleration of material originating in the host disk. Combining these observations with large-scale, optical long-slit spectroscopy that traces ionized gas emission out to several kpcs, we find that rotation kinematics dominate the majority of the gas. We find that outflowing gas extends to distances less than 1 kpc, suggesting that outflows in Seyfert galaxies may not be powerful enough to evacuate their entire bulges.

We present high resolution H-band polarized intensity (PI; FWHM = 0."1: 14 AU) and L'-band imaging data (FWHM = 0."11: 15 AU) of the circumstellar disk around the weak-lined T Tauri star PDS 70 in Centaurus at a radial distance of 28 AU (0."2) up to 210 AU (1."5). In both images, a giant inner gap is clearly resolved for the first time, and the radius of the gap is ~70 AU. Our data show that the geometric center of the disk shifts by ~6 AU toward the minor axis. We confirm that the brown dwarf companion candidate to the north of PDS 70 is a background star based on its proper motion. As a result of SED fitting by Monte Carlo radiative transfer modeling, we infer the existence of an optically thick inner disk at a few AU. Combining our observations and modeling, we classify the disk of PDS 70 as a pre-transitional disk. Furthermore, based on the analysis of L'-band imaging data, we put an upper limit mass of companions at ~30 to ~50MJ within the gap. Taking account of the presence of the large and sharp gap, we suggest that the gap could be formed by dynamical interactions of sub-stellar companions or multiple unseen giant planets in the gap.

We present new high-resolution ($\sim$0\farcs09) $H$-band imaging observations of the circumstellar disk around the T Tauri star SU Aur. Our observations with Subaru-HiCIAO have revealed the presence of scattered light as close as 0\farcs15 ($\sim$20 AU) to the star. Within our image, we identify bright emission associated with a disk with a minimum radius of $\sim$90 AU, an inclination of $\sim$35\degr from the plane of the sky, and an approximate P.A. of 15\degr for the major axis. We find a brightness asymmetry between the northern and southern sides of the disk due to a non-axisymmetric disk structure. We also identify a pair of asymmetric tail structures extending east and west from the disk. The western tail extends at least 2\farcs5 (350 AU) from the star, and is probably associated with a reflection nebula previously observed at optical and near-IR wavelengths. The eastern tail extends at least 1\arcsec (140 AU) at the present signal-to-noise. These tails are likely due to an encounter with an unseen brown dwarf, but our results do not exclude the explanation that these tails are outflow cavities or jets.

Debris disks are exoplanetary systems that contain planets, minor bodies (i.e., asteroids, Kuiper belt objects, comets, etc.), and micron-sized debris dust. Since water ice is the most common frozen volatile, it plays an essential role in the formation of planets and minor bodies. Although water ice has been commonly found in Kuiper belt objects and comets in the Solar System, no definitive evidence for water ice in debris disks has been obtained to date. Here, we report the discovery of water ice in the HD 181327 disk using the James Webb Space Telescope Near-Infrared Spectrograph. We detect the solid-state broad absorption feature of water ice at 3 $\mu$m and a distinct Fresnel peak feature at 3.1 $\mu$m, a characteristic of large water-ice particles. This implies the presence of a water-ice reservoir in the HD 181327 exoKuiper belt. Gradients of water-ice features at different stellocentric distances reveal a dynamic process of destroying and replenishing water ice in the disk, with estimated water-ice mass fractions ranging from 0.1% at ~85 au to 14% at ~113 au. It is highly plausible that the icy bodies that release water ice in HD 181327 could be the extra-solar counterparts of some of the Kuiper belt objects in our Solar System, supported by their spectral similarity.

The capability of the Fermi Gamma-ray Burst Monitor (GBM) to localize gamma-ray bursts (GRBs) is evaluated for two different automated algorithms: the GBM Team's RoboBA algorithm and the independently developed BALROG algorithm. Through a systematic study utilizing over 500 GRBs with known locations from instruments like Swift and the Fermi LAT, we directly compare the effectiveness of, and accurately estimate the systematic uncertainty for, both algorithms. We show simple adjustments to the GBM Team's RoboBA, in operation since early 2016, yields significant improvement in the systematic uncertainty, removing the long tail identified in the systematic, and improves the overall accuracy. The systematic uncertainty for the updated RoboBA localizations is $1.8^\circ$ for 52% of GRBs and $4.1^\circ$ for the remaining 48%. Both from public reporting by BALROG and our systematic study, we find the systematic uncertainty of $1-2^\circ$ quoted in GCN circulars for bright GRBs localized by BALROG is an underestimate of the true magnitude of the systematic, which we find to be $2.7^\circ$ for 74% of GRBs and $33^\circ$ for the remaining 26%. We show that, once the systematic uncertainty is considered, the RoboBA 90% localization confidence regions can be more than an order of magnitude smaller in area than those produced by BALROG.

The outer solar system provides a unique, quiet vantage point from which to observe the universe around us, where measurements could enable several niche astrophysical science cases that are too difficult to perform near Earth. NASA's New Horizons mission comprises an instrument package that provides imaging capability from ultraviolet (UV) to near-infrared (near-IR) wavelengths with moderate spectral resolution located beyond the orbit of Pluto. A carefully designed survey with New Horizons can optimize the use of expendable propellant and the limited data telemetry bandwidth to allow several measurements, including a detailed understanding of the cosmic extragalactic background light; studies of the local and extragalactic UV background; measurements of the properties of dust and ice in the outer solar system; confirmation and characterization of transiting exoplanets; determinations of the mass of dark objects using gravitational microlensing; and rapid follow-up of transient events. New Horizons is currently in an extended mission designed to focus on Kuiper Belt science that will conclude in 2021. The astrophysics community has a unique, generational opportunity to use this mission for astronomical observation at heliocentric distances beyond 50 au in the next decade. In this paper, we discuss the potential science cases for such an extended mission, and provide an initial assessment of the most important operational requirements and observation strategies it would require. We conclude that New Horizons is capable of transformative science, and that it would make a valuable and unique asset for astrophysical science that is unlikely to be replicated in the near future.