Background: An increasing volume of prostate biopsies and a world-wide shortage of uro-pathologists puts a strain on pathology departments. Additionally, the high intra- and inter-observer variability in grading can result in over- and undertreatment of prostate cancer. Artificial intelligence (AI) methods may alleviate these problems by assisting pathologists to reduce workload and harmonize grading. Methods: We digitized 6,682 needle biopsies from 976 participants in the population based STHLM3 diagnostic study to train deep neural networks for assessing prostate biopsies. The networks were evaluated by predicting the presence, extent, and Gleason grade of malignant tissue for an independent test set comprising 1,631 biopsies from 245 men. We additionally evaluated grading performance on 87 biopsies individually graded by 23 experienced urological pathologists from the International Society of Urological Pathology. We assessed discriminatory performance by receiver operating characteristics (ROC) and tumor extent predictions by correlating predicted millimeter cancer length against measurements by the reporting pathologist. We quantified the concordance between grades assigned by the AI and the expert urological pathologists using Cohen's kappa. Results: The performance of the AI to detect and grade cancer in prostate needle biopsy samples was comparable to that of international experts in prostate pathology. The AI achieved an area under the ROC curve of 0.997 for distinguishing between benign and malignant biopsy cores, and 0.999 for distinguishing between men with or without prostate cancer. The correlation between millimeter cancer predicted by the AI and assigned by the reporting pathologist was 0.96. For assigning Gleason grades, the AI achieved an average pairwise kappa of 0.62. This was within the range of the corresponding values for the expert pathologists (0.60 to 0.73).

Major Depressive Disorder and anxiety disorders affect millions globally, contributing significantly to the burden of mental health issues. Early screening is crucial for effective intervention, as timely identification of mental health issues can significantly improve treatment outcomes. Artificial intelligence (AI) can be valuable for improving the screening of mental disorders, enabling early intervention and better treatment outcomes. AI-driven screening can leverage the analysis of multiple data sources, including facial features in digital images. However, existing methods often rely on controlled environments or specialized equipment, limiting their broad applicability. This study explores the potential of AI models for ubiquitous depression-anxiety screening given face-centric selfies. The investigation focuses on high-risk pregnant patients, a population that is particularly vulnerable to mental health issues. To cope with limited training data resulting from our clinical setup, pre-trained models were utilized in two different approaches: fine-tuning convolutional neural networks (CNNs) originally designed for facial expression recognition and employing vision-language models (VLMs) for zero-shot analysis of facial expressions. Experimental results indicate that the proposed VLM-based method significantly outperforms CNNs, achieving an accuracy of 77.6%. Although there is significant room for improvement, the results suggest that VLMs can be a promising approach for mental health screening.