Hubei Key Laboratory of Agricultural Bioinformatics
Drug-drug interactions (DDIs) arise when multiple drugs are administered concurrently. Accurately predicting the specific mechanisms underlying DDIs (named DDI events or DDIEs) is critical for the safe clinical use of drugs. DDIEs are typically represented as textual descriptions. However, most computational methods focus more on predicting the DDIE class label over generating human-readable natural language increasing clinicians' interpretation costs. Furthermore, current methods overlook the fact that each drug assumes distinct biological functions in a DDI, which, when used as input context, can enhance the understanding of the DDIE process and benefit DDIE generation by the language model (LM). In this work, we propose a novel pairwise knowledge-augmented generative method (termed PKAG-DDI) for DDIE text generation. It consists of a pairwise knowledge selector efficiently injecting structural information between drugs bidirectionally and simultaneously to select pairwise biological functions from the knowledge set, and a pairwise knowledge integration strategy that matches and integrates the selected biological functions into the LM. Experiments on two professional datasets show that PKAG-DDI outperforms existing methods in DDIE text generation, especially in challenging inductive scenarios, indicating its practicality and generalization.
The Semantic Table Annotation (STA) task, which includes Column Type Annotation (CTA) and Cell Entity Annotation (CEA), maps table contents to ontology entities and plays important roles in various semantic applications. However, complex tables often pose challenges such as semantic loss of column names or cell values, strict ontological hierarchy requirements, homonyms, spelling errors, and abbreviations, which hinder annotation accuracy. To address these issues, this paper proposes an LLM-based agent approach for CTA and CEA. We design and implement five external tools with tailored prompts based on the ReAct framework, enabling the STA agent to dynamically select suitable annotation strategies depending on table characteristics. Experiments are conducted on the Tough Tables and BiodivTab datasets from the SemTab challenge, which contain the aforementioned challenges. Our method outperforms existing approaches across various metrics. Furthermore, by leveraging Levenshtein distance to reduce redundant annotations, we achieve a 70% reduction in time costs and a 60% reduction in LLM token usage, providing an efficient and cost-effective solution for STA.
Entity resolution (ER) is the problem of identifying and linking database records that refer to the same real-world entity. Traditional ER methods use batch processing, which becomes impractical with growing data volumes due to high computational costs and lack of real-time capabilities. In many applications, users need to resolve entities for only a small portion of their data, making full data processing unnecessary -- a scenario known as "ER-on-demand". This paper proposes FastER, an efficient ER-on-demand framework for property graphs. Our approach uses graph differential dependencies (GDDs) as a knowledge encoding language to design effective filtering mechanisms that leverage both structural and attribute semantics of graphs. We construct a blocking graph from filtered subgraphs to reduce the number of candidate entity pairs requiring comparison. Additionally, FastER incorporates Progressive Profile Scheduling (PPS), allowing the system to incrementally produce results throughout the resolution process. Extensive evaluations on multiple benchmark datasets demonstrate that FastER significantly outperforms state-of-the-art ER methods in computational efficiency and real-time processing for on-demand tasks while ensuring reliability. We make FastER publicly available at: this https URL
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