The aim of this paper is to give an overview of brain organoid computing, its characteristics, challenges, as well as possible advantages for future applications in the field of artificial intelligence. An important part is the extensive bibliography covering all relevant aspects and questions on this topic. Brain organoids - three-dimensional in vitro neural structures derived from human stem cells - have recently garnered attention not only in medical research but also as potential substrates for unconventional computing. Their biological nature allows them to exhibit learning behavior, plasticity, and parallel information processing, making them fundamentally different from traditional silicon-based systems. This opens up new perspectives on how intelligent systems might be designed in the future. Using brain organoids for computing presents a possible pathway towards more adaptive, energy-efficient, and biologically inspired forms of AI. However, challenges persist, particularly regarding lifespan, interfacing, reproducibility, and ethical concerns regarding the use of human-derived tissue. This paper aims to provide a foundational understanding for researchers exploring the convergence of human biology and computation.

Genetic information is encoded in a linear sequence of nucleotides, represented by letters ranging from thousands to billions. Mutations refer to changes in the DNA or RNA nucleotide sequence. Thus, mutation detection is vital in all areas of biology and medicine. Careful monitoring of virulence-enhancing mutations is essential. However, an enormous amount of classical computing power is required to analyze genetic sequences of this size. Inspired by human perception of vision and pixel representation of images on quantum computers, we leverage these techniques to implement a pairwise sequence analysis. The methodology has a potential advantage over classical approaches and can be further applied to identify mutations and other modifications in genetic sequences. We present a method to display and analyze the similarity between two genome sequences on a quantum computer where a similarity score is calculated to determine the similarity between nucleotides.

Oscillator based Ising machines are non-von-Neumann machines ideally suited for solving combinatorial problems otherwise intractable on classic stored-program digital computers due to their run-time complexity. Possible future applications are manifold ranging from quantum simulations to protein folding and are of high academic and commercial interest as well. Described in the following is a very simple such machine aimed at educational and research applications.

This study examines conversational business analytics, an approach that utilizes AI to address the technical competency gaps that hinder end users from effectively using traditional self-service analytics. By facilitating natural language interactions, conversational business analytics aims to empower end users to independently retrieve data and generate insights. The analysis focuses on Text-to-SQL as a representative technology for translating natural language requests into SQL statements. Developing theoretical models grounded in expected utility theory, this study identifies the conditions under which conversational business analytics, through partial or full support, can outperform delegation to human experts. The results indicate that partial support, focusing solely on information generation by AI, is viable when the accuracy of AI-generated SQL queries leads to a profit that surpasses the performance of a human expert. In contrast, full support includes not only information generation but also validation through explanations provided by the AI, and requires sufficiently high validation effectiveness to be reliable. However, user-based validation presents challenges, such as misjudgment and rejection of valid SQL queries, which may limit the effectiveness of conversational business analytics. These challenges underscore the need for robust validation mechanisms, including improved user support, automated processes, and methods for assessing quality independent of the technical competency of end users.

Large language models (LLMs) show promise for supporting clinical decision-making in complex fields such as rheumatology. Our evaluation shows that smaller language models (SLMs), combined with retrieval-augmented generation (RAG), achieve higher diagnostic and therapeutic performance than larger models, while requiring substantially less energy and enabling cost-efficient, local deployment. These features are attractive for resource-limited healthcare. However, expert oversight remains essential, as no model consistently reached specialist-level accuracy in rheumatology.