Reinforcement learning (RL) enables adaptive behavior across species via reward prediction errors (RPEs), but the neural origins of species-specific adaptability remain unknown. Integrating RL modeling, transcriptomics, and neuroimaging during reversal learning, we discovered convergent RPE signatures - shared monoaminergic/synaptic gene upregulation and neuroanatomical representations, yet humans outperformed macaques behaviorally. Single-trial decoding showed RPEs guided choices similarly in both species, but humans disproportionately recruited dorsal anterior cingulate (dACC) and dorsolateral prefrontal cortex (dlPFC). Cross-species alignment uncovered that macaque prefrontal circuits encode human-like optimal RPEs yet fail to translate them into action. Adaptability scaled not with RPE encoding fidelity, but with the areal extent of dACC/dlPFC recruitment governing RPE-to-action transformation. These findings resolve an evolutionary puzzle: behavioral performance gaps arise from executive cortical readout efficiency, not encoding capacity.

Metal artifacts in CT slices have long posed challenges in medical diagnostics. These artifacts degrade image quality, resulting in suboptimal visualization and complicating the accurate interpretation of tissues adjacent to metal implants. To address these issues, we introduce the Latent Gemstone Spectral Imaging (GSI) Alignment Framework, which effectively reduces metal artifacts while avoiding the introduction of noise information. Our work is based on a key finding that even artifact-affected ordinary CT sequences contain sufficient information to discern detailed structures. The challenge lies in the inability to clearly represent this information. To address this issue, we developed an Alignment Framework that adjusts the representation of ordinary CT images to match GSI CT sequences. GSI is an advanced imaging technique using multiple energy levels to mitigate artifacts caused by metal implants. By aligning the representation to GSI data, we can effectively suppress metal artifacts while clearly revealing detailed structure, without introducing extraneous information into CT sequences. To facilitate the application, we propose a new dataset, Artifacts-GSI, captured from real patients with metal implants, and establish a new benchmark based on this dataset. Experimental results show that our method significantly reduces metal artifacts and greatly enhances the readability of CT slices. All our code and data are available at: this https URL

Automatic medical image segmentation plays a critical role in scientific research and medical care. Existing high-performance deep learning methods typically rely on large training datasets with high-quality manual annotations, which are difficult to obtain in many clinical applications. Here, we introduce Annotation-effIcient Deep lEarning (AIDE), an open-source framework to handle imperfect training datasets. Methodological analyses and empirical evaluations are conducted, and we demonstrate that AIDE surpasses conventional fully-supervised models by presenting better performance on open datasets possessing scarce or noisy annotations. We further test AIDE in a real-life case study for breast tumor segmentation. Three datasets containing 11,852 breast images from three medical centers are employed, and AIDE, utilizing 10% training annotations, consistently produces segmentation maps comparable to those generated by fully-supervised counterparts or provided by independent radiologists. The 10-fold enhanced efficiency in utilizing expert labels has the potential to promote a wide range of biomedical applications.

The morbidity of brain stroke increased rapidly in the past few years. To help specialists in lesion measurements and treatment planning, automatic segmentation methods are critically required for clinical practices. Recently, approaches based on deep learning and methods for contextual information extraction have served in many image segmentation tasks. However, their performances are limited due to the insufficient training of a large number of parameters, which sometimes fail in capturing long-range dependencies. To address these issues, we propose a depthwise separable convolution based X-Net that designs a nonlocal operation namely Feature Similarity Module (FSM) to capture long-range dependencies. The adopted depthwise convolution allows to reduce the network size, while the developed FSM provides a more effective, dense contextual information extraction and thus facilitates better segmentation. The effectiveness of X-Net was evaluated on an open dataset Anatomical Tracings of Lesions After Stroke (ATLAS) with superior performance achieved compared to other six state-of-the-art approaches. We make our code and models available at this https URL.