A significant advancement in Neural Network (NN) research is the integration of domain-specific knowledge through custom loss functions. This approach addresses a crucial challenge: how can models utilize physics or mathematical principles to enhance predictions when dealing with sparse, noisy, or incomplete data? Physics-Informed Neural Networks (PINNs) put this idea into practice by incorporating physical equations, such as Partial Differential Equations (PDEs), as soft constraints. This guidance helps the networks find solutions that align with established laws. Recently, researchers have expanded this framework to include Bayesian NNs (BNNs), which allow for uncertainty quantification while still adhering to physical principles. But what happens when the governing equations of a system are not known? In this work, we introduce methods to automatically extract PDEs from historical data. We then integrate these learned equations into three different modeling approaches: PINNs, Bayesian-PINNs (B-PINNs), and Bayesian Linear Regression (BLR). To assess these frameworks, we evaluate them on a real-world Multivariate Time Series (MTS) dataset. We compare their effectiveness in forecasting future states under different scenarios: with and without PDE constraints and accuracy considerations. This research aims to bridge the gap between data-driven discovery and physics-guided learning, providing valuable insights for practical applications.

Digital Twins (DTs) are virtual representations of physical systems synchronized in real time through Internet of Things (IoT) sensors and computational models. In industrial applications, DTs enable predictive maintenance, fault diagnosis, and process optimization. This paper explores the mathematical foundations of DTs, hybrid modeling techniques, including Physics Informed Neural Networks (PINNs), and their implementation in industrial scenarios. We present key applications, computational tools, and future research directions.

Neural Networks (NN) has been used in many areas with great success. When a NN's structure (Model) is given, during the training steps, the parameters of the model are determined using an appropriate criterion and an optimization algorithm (Training). Then, the trained model can be used for the prediction or inference step (Testing). As there are also many hyperparameters, related to the optimization criteria and optimization algorithms, a validation step is necessary before its final use. One of the great difficulties is the choice of the NN's structure. Even if there are many "on the shelf" networks, selecting or proposing a new appropriate network for a given data, signal or image processing, is still an open problem. In this work, we consider this problem using model based signal and image processing and inverse problems methods. We classify the methods in five classes, based on: i) Explicit analytical solutions, ii) Transform domain decomposition, iii) Operator Decomposition, iv) Optimization algorithms unfolding, and v) Physics Informed NN methods (PINN). Few examples in each category are explained.