An ideal safe workplace is described as a place where staffs fulfill responsibilities in a well-organized order, potential hazardous events are being monitored in real-time, as well as the number of accidents and relevant damages are minimized. However, occupational-related death and injury are still increasing and have been highly attended in the last decades due to the lack of comprehensive safety management. A smart safety management system is therefore urgently needed, in which the staffs are instructed to fulfill responsibilities as well as automating risk evaluations and alerting staffs and departments when needed. In this paper, a smart system for safety management in the workplace based on responsibility big data analysis and the internet of things (IoT) are proposed. The real world implementation and assessment demonstrate that the proposed systems have superior accountability performance and improve the responsibility fulfillment through real-time supervision and self-reminder.

Alzheimer's Disease (AD) is an irreversible neurodegenerative disease characterized by progressive cognitive decline as its main symptom. In the research field of deep learning-assisted diagnosis of AD, traditional convolutional neural networks and simple feature concatenation methods fail to effectively utilize the complementary information between multimodal data, and the simple feature concatenation approach is prone to cause the loss of key information during the process of modal fusion. In recent years, the development of deep learning technology has brought new possibilities for solving the problem of how to effectively fuse multimodal features. This paper proposes a novel deep learning algorithm framework to assist medical professionals in AD diagnosis. By fusing medical multi-view information such as brain fluorodeoxyglucose positron emission tomography (PET), magnetic resonance imaging (MRI), genetic data, and clinical data, it can accurately detect the presence of AD, Mild Cognitive Impairment (MCI), and Cognitively Normal (CN). The innovation of the algorithm lies in the use of an asymmetric cross-modal cross-attention mechanism, which can effectively capture the key information features of the interactions between different data modal features. This paper compares the asymmetric cross-modal cross-attention mechanism with the traditional algorithm frameworks of unimodal and multimodal deep learning models for AD diagnosis, and evaluates the importance of the asymmetric cross-modal cross-attention mechanism. The algorithm model achieves an accuracy of 94.88% on the test set.

Breast cancer is the second leading cause of cancer-related death after lung cancer in women. Early detection of breast cancer in X-ray mammography is believed to have effectively reduced the mortality rate. However, a relatively high false positive rate and a low specificity in mammography technology still exist. In this work, a computer-aided automatic mammogram analysis system is proposed to process the mammogram images and automatically discriminate them as either normal or cancerous, consisting of three consecutive image processing, feature selection, and image classification stages. In designing the system, the discrete wavelet transforms (Daubechies 2, Daubechies 4, and Biorthogonal 6.8) and the Fourier cosine transform were first used to parse the mammogram images and extract statistical features. Then, an entropy-based feature selection method was implemented to reduce the number of features. Finally, different pattern recognition methods (including the Back-propagation Network, the Linear Discriminant Analysis, and the Naive Bayes Classifier) and a voting classification scheme were employed. The performance of each classification strategy was evaluated for sensitivity, specificity, and accuracy and for general performance using the Receiver Operating Curve. Our method is validated on the dataset from the Eastern Health in Newfoundland and Labrador of Canada. The experimental results demonstrated that the proposed automatic mammogram analysis system could effectively improve the classification performances.

Recent studies in big data analytics and natural language processing develop automatic techniques in analyzing sentiment in the social media information. In addition, the growing user base of social media and the high volume of posts also provide valuable sentiment information to predict the price fluctuation of the cryptocurrency. This research is directed to predicting the volatile price movement of cryptocurrency by analyzing the sentiment in social media and finding the correlation between them. While previous work has been developed to analyze sentiment in English social media posts, we propose a method to identify the sentiment of the Chinese social media posts from the most popular Chinese social media platform Sina-Weibo. We develop the pipeline to capture Weibo posts, describe the creation of the crypto-specific sentiment dictionary, and propose a long short-term memory (LSTM) based recurrent neural network along with the historical cryptocurrency price movement to predict the price trend for future time frames. The conducted experiments demonstrate the proposed approach outperforms the state of the art auto regressive based model by 18.5% in precision and 15.4% in recall.

Objective: To investigate the mechanism by which quercetin inhibits triple-negative breast cancer (TNBC) through regulating T-cell-related targets, providing a novel strategy for TNBC this http URL: Single-cell RNA sequencing (GSE161529 dataset) and network pharmacology were integrated. PCA and UMAP clustering identified T-cell subsets and differentially expressed genes in TNBC microenvironment. TNBC-related targets were screened via CTD and OMIM databases, with functional pathways analyzed by GO/KEGG enrichment. Molecular docking and PPI networks validated interactions between quercetin and core this http URL: Quercetin intersected with 79 TNBC targets, including AKT1, EGFR, and MMP9, enriched in EGFR inhibitor resistance and endocrine resistance pathways. Molecular docking revealed the highest affinity between quercetin and GSK3B (-13.2 kJ/mol). AKT1 and MMP9 expression correlated with patient this http URL: Quercetin may reverse TNBC immunosuppression by multi-target modulation of T-cell function, but clinical application requires solutions for its low bioavailability, such as delivery systems or combination therapies.