Nagasaki University
Artificial Intelligence (AI) is revolutionizing various fields, including public health surveillance. In Africa, where health systems frequently encounter challenges such as limited resources, inadequate infrastructure, failed health information systems and a shortage of skilled health professionals, AI offers a transformative opportunity. This paper investigates the applications of AI in public health surveillance across the continent, presenting successful case studies and examining the benefits, opportunities, and challenges of implementing AI technologies in African healthcare settings. Our paper highlights AI's potential to enhance disease monitoring and health outcomes, and support effective public health interventions. The findings presented in the paper demonstrate that AI can significantly improve the accuracy and timeliness of disease detection and prediction, optimize resource allocation, and facilitate targeted public health strategies. Additionally, our paper identified key barriers to the widespread adoption of AI in African public health systems and proposed actionable recommendations to overcome these challenges.
Background: Providing appropriate care for people suffering from COVID-19, the disease caused by the pandemic SARS-CoV-2 virus is a significant global challenge. Many individuals who become infected have pre-existing conditions that may interact with COVID-19 to increase symptom severity and mortality risk. COVID-19 patient comorbidities are likely to be informative about individual risk of severe illness and mortality. Accurately determining how comorbidities are associated with severe symptoms and mortality would thus greatly assist in COVID-19 care planning and provision. Methods: To assess the interaction of patient comorbidities with COVID-19 severity and mortality we performed a meta-analysis of the published global literature, and machine learning predictive analysis using an aggregated COVID-19 global dataset. Results: Our meta-analysis identified chronic obstructive pulmonary disease (COPD), cerebrovascular disease (CEVD), cardiovascular disease (CVD), type 2 diabetes, malignancy, and hypertension as most significantly associated with COVID-19 severity in the current published literature. Machine learning classification using novel aggregated cohort data similarly found COPD, CVD, CKD, type 2 diabetes, malignancy and hypertension, as well as asthma, as the most significant features for classifying those deceased versus those who survived COVID-19. While age and gender were the most significant predictor of mortality, in terms of symptom-comorbidity combinations, it was observed that Pneumonia-Hypertension, Pneumonia-Diabetes and Acute Respiratory Distress Syndrome (ARDS)-Hypertension showed the most significant effects on COVID-19 mortality. Conclusions: These results highlight patient cohorts most at risk of COVID-19 related severe morbidity and mortality which have implications for prioritization of hospital resources.
Can a welfare-maximising risk-sharing rule be implemented in a large, decentralised community? We revisit the price-and-choose (P&C) mechanism of Echenique and Núñez (2025), in which players post price schedules sequentially and the last mover selects an allocation. P&C implements every Pareto-optimal allocation when the choice set is finite, but realistic risk-sharing problems involve an infinite continuum of feasible allocations. We extend P&C to infinite menus by modelling each allocation as a bounded random vector that redistributes an aggregate loss X=iXiX=\sum_i X_i. We prove that the extended mechanism still implements the allocation that maximises aggregate (monetary) utility, even when players entertain heterogeneous credal sets of finitely additive probabilities (charges) dominated by a reference probability P\mathbb{P}. Our credal sets are weak^{\ast}-compact and are restricted so that expectation functionals are uniformly Lipschitz on the feasible set. Finally, we pair P&C with the first-mover auction of Echenique and Núñez (2025), adapted to our infinite-menu, multiple-prior environment. With a public signal about the common surplus, the auction equalises (conditional) expected surplus among participants. The result is a decentralised, enforcement-free procedure that achieves both optimal and fair risk sharing under heterogeneous priors.
We examine the linear stability of a filamentary cloud permeated by a perpendicular magnetic field. The initial magnetic field is assumed to be uniform and perpendicular to the cloud axis. The model cloud is assumed to have a Plummer-like density profile and to be supported against the self-gravity by turbulence. The effects of turbulence are taken into account by enhancing the effective pressure of a low density gas. We derive the effective pressure as a function of the density from the condition of the hydrostatic balance. It is shown that the model cloud is more unstable against radial collapse, when the radial density slope is shallower. When the magnetic field is mildly strong, the radial collapse is suppressed. If the displacement vanishes in the region very far from the cloud axis, the model cloud is stabilized completely by a mildly strong magnetic field. If rearrangement of the magnetic flux tubes is permitted, the model cloud is unstable even when the magnetic field is extremely strong. The stability depends on the outer boundary condition as in case of the isothermal cloud. The growth rate of the rearrangement mode is smaller when the radial density slope is shallower.
After the end of World War II, the commitment to confine scientific activities in universities and research institutions to peaceful and civilian purposes has entered, in the form of {\it Civil Clauses}, the charters of many research institutions and universities. In the wake of recent world events, the relevance and scope of such Civil Clauses has been questioned in reports issued by some governments and by the EU Commission, a development that opens the door to a possible blurring of the distinction between peaceful and military research. This paper documents the reflections stimulated by a panel discussion on this issue recently organized by the Science4Peace Forum. We review the adoptions of Civil Clauses in research organizations and institutions in various countries, present evidence of the challenges that are emerging to such Civil Clauses, and collect arguments in favour of maintaining the purely civilian and peaceful focus of public (non-military) research.
Recent observations show that the space density of luminous active galactic nuclei (AGNs) peaks at higher redshifts than that of faint AGNs. This downsizing trend in the AGN evolution seems to be contradictory to the hierarchical structure formation scenario. In this study, we present the AGN space density evolution predicted by a semi-analytic model of galaxy and AGN formation based on the hierarchical structure formation scenario. We demonstrate that our model can reproduce the downsizing trend of the AGN space density evolution. The reason for the downsizing trend in our model is a combination of the cold gas depletion as a consequence of star formation, the gas cooling suppression in massive halos and the AGN lifetime scaling with the dynamical timescale. We assume that a major merger of galaxies causes a starburst, spheroid formation, and cold gas accretion onto a supermassive black hole (SMBH). We also assume that this cold gas accretion triggers AGN activity. Since the cold gas is mainly depleted by star formation and gas cooling is suppressed in massive dark halos, the amount of cold gas accreted onto SMBHs decreases with cosmic time. Moreover, AGN lifetime increases with cosmic time. Thus, at low redshifts, major mergers do not always lead to luminous AGNs. Because the luminosity of AGNs is correlated with the mass of accreted gas onto SMBHs, the space density of luminous AGNs decreases more quickly than that of faint AGNs. We conclude that the anti-hierarchical evolution of the AGN space density is not contradictory to the hierarchical structure formation scenario.
We present the evolution of dark matter halos in six large cosmological N-body simulations, called the ν2\nu^2GC (New Numerical Galaxy Catalog) simulations on the basis of the LCDM cosmology consistent with observational results obtained by the Planck satellite. The largest simulation consists of 819238192^3 (550 billion) dark matter particles in a box of $1.12 \, h^{-1} \rm Gpc(amassresolutionof (a mass resolution of 2.20 \times 10^{8} \, h^{-1} M_{\odot}$). Among simulations utilizing boxes larger than 1h1Gpc1 \, h^{-1} \rm Gpc, our simulation yields the highest resolution simulation that has ever been achieved. A ν2\nu^2GC simulation with the smallest box consists of eight billions particles in a box of 70h1Mpc70 \, h^{-1} \rm Mpc (a mass resolution of $3.44 \times 10^{6} \, h^{-1} M_{\odot}$). These simulations can follow the evolution of halos over masses of eight orders of magnitude, from small dwarf galaxies to massive clusters. Using the unprecedentedly high resolution and powerful statistics of the ν2\nu^2GC simulations, we provide statistical results of the halo mass function, mass accretion rate, formation redshift, and merger statistics, and present accurate fitting functions for the Planck cosmology. By combining the ν2\nu^2GC simulations with our new semi-analytic galaxy formation model, we are able to prepare mock catalogs of galaxies and active galactic nuclei, which will be made publicly available in the near future.
A compact binary in an eccentric orbit radiates gravitational waves (GWs) at all integer harmonics of its orbital frequency. In this study, we investigate the effect of orbital eccentricity on the expected gravitational background radiation (GWBR) from supermassive black hole (SMBH) binaries in the nuclei of galaxies. For this purpose, we formulate a power spectrum of the GWBR from cosmological evolving eccentric binaries. Then, we apply this formulation to the case of the GWBR from SMBH binaries. The key to doing this is to correctly estimate the number density of coalescing SMBH binaries. In this study, we use a semi-analytic model of galaxy and SMBH formation. We find that the power spectrum of the GWBR from SMBH binaries on eccentric orbits is suppressed for frequencies f1 nHzf \lesssim 1~{\rm nHz} if the initial eccentricity, e0e_0, satisfies e0>0.2e_0 > 0.2 and the initial semi-major axis is 300 times Scwarzschild radius. Our model predicts that while the overall shape and amplitude of the power spectrum depend strongly on the processes of galaxy formation, the eccentricity of binaries can affect the shape of the power spectrum for lower frequencies, i.e., f1 nHzf \lesssim 1~{\rm nHz}. Pulsar timing measurements, which can detect GW in this frequency range, could constrain the effect of eccentricity on the power spectrum of the GWBR from SMBH binaries.
We present a new cosmological galaxy formation model, ν2\nu^2GC, as an updated version of our previous model ν\nuGC. We adopt the so-called "semi-analytic" approach, in which the formation history of dark matter halos is computed by N{\it N}-body simulations, while the baryon physics such as gas cooling, star formation and supernova feedback are simply modeled by phenomenological equations. Major updates of the model are as follows: (1) the merger trees of dark matter halos are constructed in state-of-the-art ${\it N}$-body simulations, (2) we introduce the formation and evolution process of supermassive black holes and the suppression of gas cooling due to active galactic nucleus (AGN) activity, (3) we include heating of the intergalactic gas by the cosmic UV background, and (4) we tune some free parameters related to the astrophysical processes using a Markov chain Monte Carlo method. Our N{\it N}-body simulations of dark matter halos have unprecedented box size and mass resolution (the largest simulation contains 550 billion particles in a 1.12 Gpc/h box), enabling the study of much smaller and rarer objects. The model was tuned to fit the luminosity functions of local galaxies and mass function of neutral hydrogen. Local observations, such as the Tully-Fisher relation, size-magnitude relation of spiral galaxies and scaling relation between the bulge mass and black hole mass were well reproduced by the model. Moreover, the model also well reproduced the cosmic star formation history and the redshift evolution of rest-frame K{\it K}-band luminosity functions. The numerical catalog of the simulated galaxies and AGNs is publicly available on the web.
Magnetic field is ubiquitous in the Universe and it plays essential roles in various astrophysical phenomena, yet its real origin and evolution are poorly known. This article reviews current understanding of magnetic fields in the interstellar medium, the Milky Way Galaxy, external galaxies, active galactic nuclei, clusters of galaxies, and the cosmic web. Particularly, the review concentrates on the achievements that have been provided by centimeter and meter wavelength radio observations. The article also introduces various methods to analyze linear polarization data, including synchrotron radiation, Faraday rotation, depolarization, and Faraday tomography.
We examine the linear stability of an isothermal filamentary cloud permeated by a perpendicular magnetic field. Our model cloud is assumed to be supported by gas pressure against the self-gravity in the unperturbed state. For simplicity, the density distribution is assumed to be symmetric around the axis. Also for simplicity, the initial magnetic field is assumed to be uniform and turbulence is not taken into account. The perturbation equation is formulated to be an eigenvalue problem. The growth rate is obtained as a function of the wavenumber for fragmentation along the axis and the magnetic field strength. The growth rate depends critically on the outer boundary. If the displacement vanishes in the region very far from the cloud axis (fixed boundary), cloud fragmentation is suppressed by a moderate magnetic field, which means the plasma beta is below 1.67 on the cloud axis. If the displacement is constant along the magnetic field in the region very far from the cloud, the cloud is unstable even when the magnetic field is infinitely strong. The cloud is deformed by circulation in the plane perpendicular to the magnetic field. The unstable mode is not likely to induce dynamical collapse, since it is excited even when the whole cloud is magnetically subcritical. For both the boundary conditions the magnetic field increases the wavelength of the most unstable mode. We find that the magnetic force suppresses compression perpendicular to the magnetic field especially in the region of low density.
We introduce a new stereo formulation which does not use pixel and disparity models. Many problems in vision are treated as assigning each pixel a label. Disparities are labels for stereo. Such pixel-labeling problems are naturally represented in terms of energy minimization, where the energy function has two terms: one term penalizes solutions that inconsistent with the observed data, the other term enforces spatial smoothness. Graph cuts are one of the effi- cient methods for solving energy minimization. However, exact minimization of multi labeling problems can be performed by graph cuts only for the case with convex smoothness terms. In pixel-disparity formulation, convex smoothness terms do not generate well reconstructed 3D results. Thus, truncated linear or quadratic smoothness terms, etc. are used, where approximate energy minimization is necessary. In this paper, we introduce a new site-labeling formulation, where the sites are not pixels but lines in 3D space, labels are not disparities but depth numbers. For this formulation, visibility reasoning is naturally included in the energy function. In addition, this formulation allows us to use a small smoothness term, which does not affect the 3D results much. This makes the optimization step very simple, so we could develop an approximation method for graph cut itself (not for energy minimization) and a high performance GPU graph cut program. For Tsukuba stereo pair in Middlebury data set, we got the result in 5ms using GTX1080GPU, 19ms using GTX660GPU.
The origin of the narrow Fe-K{\alpha} fluorescence line at 6.4 keV from active galactic nuclei has long been under debate; some of the possible sites are the outer accretion disk, the broad line region, a molecular torus, or interstellar/intracluster media. In February-March 2016, we performed the first X-ray microcalorimeter spectroscopy with the Soft X-ray Spectrometer (SXS) onboard the Hitomi satellite of the Fanaroff-Riley type I radio galaxy NGC 1275 at the center of the Perseus cluster of galaxies. With the high energy resolution of ~5 eV at 6 keV achieved by Hitomi/SXS, we detected the Fe-K{\alpha} line with ~5.4 {\sigma} significance. The velocity width is constrained to be 500-1600 km s1^{-1} (FWHM for Gaussian models) at 90% confidence. The SXS also constrains the continuum level from the NGC 1275 nucleus up to ~20 keV, giving an equivalent width ~20 eV of the 6.4 keV line. Because the velocity width is narrower than that of broad H{\alpha} line of ~2750 km s1^{-1}, we can exclude a large contribution to the line flux from the accretion disk and the broad line region. Furthermore, we performed pixel map analyses on the Hitomi/SXS data and image analyses on the Chandra archival data, and revealed that the Fe-K{\alpha} line comes from a region within ~1.6 kpc from the NGC 1275 core, where an active galactic nucleus emission dominates, rather than that from intracluster media. Therefore, we suggest that the source of the Fe-K{\alpha} line from NGC 1275 is likely a low-covering fraction molecular torus or a rotating molecular disk which probably extends from a pc to hundreds pc scale in the active galactic nucleus system.
This analytical study investigates the "Ashfall" hypothesis, demonstrating that magnetohydrodynamic (MHD) outflows from protoplanetary disks can lift and transport millimeter-sized dust grains into protostellar envelopes. The research provides a theoretical explanation for the observed presence of large dust grains in these environments and quantifies the maximum dust size lifted based on various outflow and stellar parameters.
This paper investigates the expressive power of a minimal fragment of separation logic extended with natural numbers. Specifically, it demonstrates that the fragment consisting solely of the intuitionistic points-to predicate, the constant 0, and the successor function is sufficient to encode all Π10\Pi^0_1 formulas of Peano Arithmetic (PA). The authors construct a translation from PA into this fragment, showing that a Π10\Pi^0_1 formula is valid in the standard model of arithmetic if and only if its translation is valid in the standard interpretation of the separation logic fragment. This result implies the undecidability of validity in the fragment, despite its syntactic simplicity. The translation leverages a heap-based encoding of arithmetic operations - addition, multiplication, and inequality - using structured memory cells. The paper also explores the boundaries of this encoding, showing that the translation does not preserve validity for Σ10\Sigma^0_1 formulas. Additionally, an alternative undecidability proof is presented via a reduction from finite model theory. Finally, the paper establishes that the validity problem for this fragment is Π10\Pi^0_1-complete, highlighting its theoretical significance in the landscape of logic and program verification.
Increasingly, high value industrial markets are driving trends for improved functionality and resilience from resident autonomous systems. This led to an increase in multi-robot fleets that aim to leverage the complementary attributes of the diverse platforms. In this paper we introduce a novel bio-inspired Symbiotic System of Systems Approach (SSOSA) for designing the operational governance of a multi-robot fleet consisting of ground-based quadruped and wheeled platforms. SSOSA couples the MR-fleet to the resident infrastructure monitoring systems into one collaborative digital commons. The hyper visibility of the integrated distributed systems, achieved through a latency bidirectional communication network, supports collaboration, coordination and corroboration (3C) across the integrated systems. In our experiment, we demonstrate how an operator can activate a pre-determined autonomous mission and utilize SSOSA to overcome intrinsic and external risks to the autonomous missions. We demonstrate how resilience can be enhanced by local collaboration between SPOT and Husky wherein we detect a replacement battery, and utilize the manipulator arm of SPOT to support a Clearpath Husky A200 wheeled robotic platform. This allows for increased resilience of an autonomous mission as robots can collaborate to ensure the battery state of the Husky robot. Overall, these initial results demonstrate the value of a SSOSA approach in addressing a key operational barrier to scalable autonomy, the resilience.
We present theoretical predictions of UV continuum luminosity function (UV LF) and Lya equivalent width (EW) distribution of Lyman alpha emitters (LAEs) in the framework of the hierarchical clustering model of galaxy formation. The model parameters about LAEs were determined by fitting to the observed Lya LF at z=5.7 in our previous study, and the fit indicates that extinction of Lya photons by dust is significantly less effective than that of UV continuum photons, implying clumpy dust distribution in interstellar medium. We then compare the predictions about UV LFs and EW distributions with a variety of observations at z ~ 3-6, allowing no more free parameters and paying careful attention to the selection conditions of LAEs in each survey. We find that the predicted UV LFs and EW distributions are in nice agreement with observed data, and especially, our model naturally reproduces the existence of large EW LAEs (> 240 A) without introducing Pop III stars or top-heavy initial mass function. We show that both the stellar population (young age and low metallicity) and extinction by clumpy dust are the keys to reproduce large EW LAEs. The evidence of EW enhancement by clumpy dust is further strengthened by the quantitative agreement between our model and recent observations about a positive correlation between EW and extinction. The observed trend that brighter LAEs in UV continuum tend to have smaller mean EW is also reproduced, and the clumpy dust is playing an important role again for this trend. We suggested in our previous study that the transmission of intergalactic medium for Lya emission rapidly decreases from z ~ 6 to 7 by the fitting to Lya LFs, and this evidence is quantitatively strengthened by the comparison with the UV LF and EW distribution at z ~ 6.6.
20 Feb 2001
This study explains the repetitive rebrightening and abrupt cessation of mini-outbursts observed in the WZ Sge-type dwarf nova EG Cancri following its 1996/1997 main outburst. Researchers propose the phenomenon results from the exponential decay and subsequent regeneration of magnetic field-driven viscosity in the accretion disk, successfully reproducing the six mini-outbursts and their 7-day recurrence interval, and attributing their sudden end to subtle stochastic variations in viscosity regeneration.
The magnetic moment and spin-polarized electron transport properties of triangular graphene flakes surrounded by boron nitride sheets (BNC structures) are studied by using first-principles calculations based on density functional theory. Their dependence on the BNC structure is discussed, revealing that small isolated graphene flakes have large magnetic moment. When the BNC structure is suspended between graphene electrodes, the spin-polarized charge density distribution accumulates at the edge of the graphene flakes and no spin polarization is observed in the graphene electrodes. We also found that the BNC structure demonstrates perfectly spin-polarized transport properties in the wide energy window around the Fermi level. Our first-principles results indicate that the BNC structure provides new possibilities to electrically control spin.
14 Dec 2001
Photometric humps in outburst that are locked with the binary orbital period have been observed exclusively in the early phase of outbursts of WZ Sge stars. It is suggested that this "early hump" phenomenon is the manifestation of the tidal 2:1 resonance in accretion disks of binary systems with extremely low mass ratios. The "early humps" can be understood by the two-armed spiral pattern of tidal dissipation generated by the 2:1 resonance, first discussed by Lin & Papaloizou (1979). The tidal removal of angular momentum from the disk during outbursts of dwarf novae, an important feature, is discussed in the context of the disk instability model. The ordering of tidal truncation radius, the 3:1 and 2:1 resonance radius in systems of different mass ratio naturally leads to a classification of dwarf nova systems in three groups according to their mass ratio. The WZ Sge stars are those systems which have the lowest mass ratios and are therefore characterized by "early humps".
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