T cells monitor the health status of cells by identifying foreign peptides displayed on their surface. T-cell receptors (TCRs), which are protein complexes found on the surface of T cells, are able to bind to these peptides. This process is known as TCR recognition and constitutes a key step for immune response. Optimizing TCR sequences for TCR recognition represents a fundamental step towards the development of personalized treatments to trigger immune responses killing cancerous or virus-infected cells. In this paper, we formulated the search for these optimized TCRs as a reinforcement learning (RL) problem, and presented a framework TCRPPO with a mutation policy using proximal policy optimization. TCRPPO mutates TCRs into effective ones that can recognize given peptides. TCRPPO leverages a reward function that combines the likelihoods of mutated sequences being valid TCRs measured by a new scoring function based on deep autoencoders, with the probabilities of mutated sequences recognizing peptides from a peptide-TCR interaction predictor. We compared TCRPPO with multiple baseline methods and demonstrated that TCRPPO significantly outperforms all the baseline methods to generate positive binding and valid TCRs. These results demonstrate the potential of TCRPPO for both precision immunotherapy and peptide-recognizing TCR motif discovery.

The pruning objective has recently extended beyond accuracy and sparsity to robustness in language models. Despite this, existing methods struggle to enhance robustness against adversarial attacks when continually increasing model sparsity and require a retraining process. As humans step into the era of large language models, these issues become increasingly prominent. This paper proposes that the robustness of language models is proportional to the extent of pre-trained knowledge they encompass. Accordingly, we introduce a post-training pruning strategy designed to faithfully replicate the embedding space and feature space of dense language models, aiming to conserve more pre-trained knowledge during the pruning process. In this setup, each layer's reconstruction error not only originates from itself but also includes cumulative error from preceding layers, followed by an adaptive rectification. Compared to other state-of-art baselines, our approach demonstrates a superior balance between accuracy, sparsity, robustness, and pruning cost with BERT on datasets SST2, IMDB, and AGNews, marking a significant stride towards robust pruning in language models.

In recent years, many techniques have been developed to improve the performance and efficiency of data center networks. While these techniques provide high accuracy, they are often designed using heuristics that leverage domain-specific properties of the workload or hardware. In this vision paper, we argue that many data center networking techniques, e.g., routing, topology augmentation, energy savings, with diverse goals actually share design and architectural similarity. We present a design for developing general intermediate representations of network topologies using deep learning that is amenable to solving classes of data center problems. We develop a framework, DeepConfig, that simplifies the processing of configuring and training deep learning agents that use the intermediate representation to learns different tasks. To illustrate the strength of our approach, we configured, implemented, and evaluated a DeepConfig-Agent that tackles the data center topology augmentation problem. Our initial results are promising --- DeepConfig performs comparably to the optimal.

Device-to-Device (D2D) communications can increase the throughput of cellular networks significantly, where the interference among D2D links should be properly managed. In this paper, we propose an opportunistic cooperative D2D transmission strategy by exploiting the caching capability at the users to deal with the interference among D2D links. To increase the cooperative opportunity and improve spatial reuse gain, we divide the D2D users into clusters and cache different popular files at the users within a cluster, and then find the optimal cluster size. To maximize the network throughput, we assign different frequency bands to cooperative and non-cooperative D2D links and optimize the bandwidth partition. Simulation results demonstrate that the proposed strategy can provide 500%-600% throughput gain over existing cache-enabled D2D communications when the popularity distribution is skewed, and can provide 40%-80% gain even when the popularity distribution is uniform.

Given a single RGB image of a complex outdoor road scene in the perspective view, we address the novel problem of estimating an occlusion-reasoned semantic scene layout in the top-view. This challenging problem not only requires an accurate understanding of both the 3D geometry and the semantics of the visible scene, but also of occluded areas. We propose a convolutional neural network that learns to predict occluded portions of the scene layout by looking around foreground objects like cars or pedestrians. But instead of hallucinating RGB values, we show that directly predicting the semantics and depths in the occluded areas enables a better transformation into the top-view. We further show that this initial top-view representation can be significantly enhanced by learning priors and rules about typical road layouts from simulated or, if available, map data. Crucially, training our model does not require costly or subjective human annotations for occluded areas or the top-view, but rather uses readily available annotations for standard semantic segmentation. We extensively evaluate and analyze our approach on the KITTI and Cityscapes data sets.

Unarguably, deep learning models capable of generalizing to unseen domain data while leveraging a few labels are of great practical significance due to low developmental costs. In search of this endeavor, we study the challenging problem of semi-supervised domain generalization (SSDG), where the goal is to learn a domain-generalizable model while using only a small fraction of labeled data and a relatively large fraction of unlabeled data. Domain generalization (DG) methods show subpar performance under the SSDG setting, whereas semi-supervised learning (SSL) methods demonstrate relatively better performance, however, they are considerably poor compared to the fully-supervised DG methods. Towards handling this new, but challenging problem of SSDG, we propose a novel method that can facilitate the generation of accurate pseudo-labels under various domain shifts. This is accomplished by retaining the domain-level specialism in the classifier during training corresponding to each source domain. Specifically, we first create domain-level information vectors on the fly which are then utilized to learn a domain-aware mask for modulating the classifier's weights. We provide a mathematical interpretation for the effect of this modulation procedure on both pseudo-labeling and model training. Our method is plug-and-play and can be readily applied to different SSL baselines for SSDG. Extensive experiments on six challenging datasets in two different SSDG settings show that our method provides visible gains over the various strong SSL-based SSDG baselines.

Despite recent successes in synthesizing faces and bedrooms, existing generative models struggle to capture more complex image types, potentially due to the oversimplification of their latent space constructions. To tackle this issue, building on Variational Autoencoders (VAEs), we integrate recurrent connections across channels to both inference and generation steps, allowing the high-level features to be captured in global-to-local, coarse-to-fine manners. Combined with adversarial loss, our channel-recurrent VAE-GAN (crVAE-GAN) outperforms VAE-GAN in generating a diverse spectrum of high resolution images while maintaining the same level of computational efficacy. Our model produces interpretable and expressive latent representations to benefit downstream tasks such as image completion. Moreover, we propose two novel regularizations, namely the KL objective weighting scheme over time steps and mutual information maximization between transformed latent variables and the outputs, to enhance the training.

This paper presents AeroTraj, a system that enables fast, accurate, and automated reconstruction of 3D models of large buildings using a drone-mounted LiDAR. LiDAR point clouds can be used directly to assemble 3D models if their positions are accurately determined. AeroTraj uses SLAM for this, but must ensure complete and accurate reconstruction while minimizing drone battery usage. Doing this requires balancing competing constraints: drone speed, height, and orientation. AeroTraj exploits building geometry in designing an optimal trajectory that incorporates these constraints. Even with an optimal trajectory, SLAM's position error can drift over time, so AeroTraj tracks drift in-flight by offloading computations to the cloud and invokes a re-calibration procedure to minimize error. AeroTraj can reconstruct large structures with centimeter-level accuracy and with an average end-to-end latency below 250 ms, significantly outperforming the state of the art.

Simulation is a useful tool in situations where training data for machine learning models is costly to annotate or even hard to acquire. In this work, we propose a reinforcement learning-based method for automatically adjusting the parameters of any (non-differentiable) simulator, thereby controlling the distribution of synthesized data in order to maximize the accuracy of a model trained on that data. In contrast to prior art that hand-crafts these simulation parameters or adjusts only parts of the available parameters, our approach fully controls the simulator with the actual underlying goal of maximizing accuracy, rather than mimicking the real data distribution or randomly generating a large volume of data. We find that our approach (i) quickly converges to the optimal simulation parameters in controlled experiments and (ii) can indeed discover good sets of parameters for an image rendering simulator in actual computer vision applications.