We discuss the effective diffusion constant
Deff for stochastic processes with spatially-dependent noise. Starting from a stochastic process given by a Langevin equation, different drift-diffusion equations can be derived depending on the choice of the discretization rule
0≤α≤1. We initially study the case of periodic heterogeneous diffusion without drift and we determine a general result for the effective diffusion coefficient
Deff, which is valid for any value of
α. We study the case of periodic sinusoidal diffusion in detail and we find a relationship with Legendre functions. Then, we derive
Deff for general
α in the case of diffusion with periodic spatial noise and in the presence of a drift term, generalizing the Lifson-Jackson theorem. Our results are illustrated by analytical and numerical calculations on generic periodic choices for drift and diffusion terms.