Lipolysis is a life-essential metabolic process, which supplies fatty acids stored in lipid droplets to the body in order to match the demands of building new cells and providing cellular energy. In this paper, we present a first mathematical modelling approach for lipolysis, which takes into account that the involved enzymes act on the surface of lipid droplets. We postulate an active region near the surface where the substrates are within reach of the surface-bound enzymes and formulate a system of reaction-diffusion PDEs, which connect the active region to the inner core of lipid droplets via interface conditions. We establish two numerical discretisations based on finite element method and isogeometric analysis, and validate them to perform reliably. Since numerical tests are best performed on non-zero explicit stationary state solutions, we introduce and analyse a model, which describes besides lipolysis also a reverse process (yet in a physiologically much oversimplified way). The system is not coercive such that establishing well-posedness is a non-standard task. We prove the unique existence of global and equilibrium solutions. We establish exponential convergence to the equilibrium solutions using the entropy method. We then study the stationary state model and compute explicitly for radially symmetric solutions. Concerning the finite element methods, we show numerically the linear and quadratic convergence of the errors with respect to the $H^{1}$- and $L^{2}$-norms, respectively. Finally, we present numerical simulations of a prototypical PDE model of lipolysis and illustrate that ATGL clustering on lipid droplets can significantly slow down lipolysis.

For autonomous vehicles, safe navigation in complex environments depends on handling a broad range of diverse and rare driving scenarios. Simulation- and scenario-based testing have emerged as key approaches to development and validation of autonomous driving systems. Traditional scenario generation relies on rule-based systems, knowledge-driven models, and data-driven synthesis, often producing limited diversity and unrealistic safety-critical cases. With the emergence of foundation models, which represent a new generation of pre-trained, general-purpose AI models, developers can process heterogeneous inputs (e.g., natural language, sensor data, HD maps, and control actions), enabling the synthesis and interpretation of complex driving scenarios. In this paper, we conduct a survey about the application of foundation models for scenario generation and scenario analysis in autonomous driving (as of May 2025). Our survey presents a unified taxonomy that includes large language models, vision-language models, multimodal large language models, diffusion models, and world models for the generation and analysis of autonomous driving scenarios. In addition, we review the methodologies, open-source datasets, simulation platforms, and benchmark challenges, and we examine the evaluation metrics tailored explicitly to scenario generation and analysis. Finally, the survey concludes by highlighting the open challenges and research questions, and outlining promising future research directions. All reviewed papers are listed in a continuously maintained repository, which contains supplementary materials and is available at this https URL.

The SoccerNet 2025 Challenges mark the fifth annual edition of the SoccerNet open benchmarking effort, dedicated to advancing computer vision research in football video understanding. This year's challenges span four vision-based tasks: (1) Team Ball Action Spotting, focused on detecting ball-related actions in football broadcasts and assigning actions to teams; (2) Monocular Depth Estimation, targeting the recovery of scene geometry from single-camera broadcast clips through relative depth estimation for each pixel; (3) Multi-View Foul Recognition, requiring the analysis of multiple synchronized camera views to classify fouls and their severity; and (4) Game State Reconstruction, aimed at localizing and identifying all players from a broadcast video to reconstruct the game state on a 2D top-view of the field. Across all tasks, participants were provided with large-scale annotated datasets, unified evaluation protocols, and strong baselines as starting points. This report presents the results of each challenge, highlights the top-performing solutions, and provides insights into the progress made by the community. The SoccerNet Challenges continue to serve as a driving force for reproducible, open research at the intersection of computer vision, artificial intelligence, and sports. Detailed information about the tasks, challenges, and leaderboards can be found at this https URL, with baselines and development kits available at this https URL.

Reliably identifying reinforced concrete defects (RCDs)plays a crucial role in assessing the structural integrity, traffic safety, and long-term durability of concrete bridges, which represent the most common bridge type worldwide. Nevertheless, available datasets for the recognition of RCDs are small in terms of size and class variety, which questions their usability in real-world scenarios and their role as a benchmark. Our contribution to this problem is "dacl10k", an exceptionally diverse RCD dataset for multi-label semantic segmentation comprising 9,920 images deriving from real-world bridge inspections. dacl10k distinguishes 12 damage classes as well as 6 bridge components that play a key role in the building assessment and recommending actions, such as restoration works, traffic load limitations or bridge closures. In addition, we examine baseline models for dacl10k which are subsequently evaluated. The best model achieves a mean intersection-over-union of 0.42 on the test set. dacl10k, along with our baselines, will be openly accessible to researchers and practitioners, representing the currently biggest dataset regarding number of images and class diversity for semantic segmentation in the bridge inspection domain.

Recent advances in quantum computers are demonstrating the ability to solve problems at a scale beyond brute force classical simulation. As such, a widespread interest in quantum algorithms has developed in many areas, with optimization being one of the most pronounced domains. Across computer science and physics, there are a number of different approaches for major classes of optimization problems, such as combinatorial optimization, convex optimization, non-convex optimization, and stochastic extensions. This work draws on multiple approaches to study quantum optimization. Provably exact versus heuristic settings are first explained using computational complexity theory - highlighting where quantum advantage is possible in each context. Then, the core building blocks for quantum optimization algorithms are outlined to subsequently define prominent problem classes and identify key open questions that, if answered, will advance the field. The effects of scaling relevant problems on noisy quantum devices are also outlined in detail, alongside meaningful benchmarking problems. We underscore the importance of benchmarking by proposing clear metrics to conduct appropriate comparisons with classical optimization techniques. Lastly, we highlight two domains - finance and sustainability - as rich sources of optimization problems that could be used to benchmark, and eventually validate, the potential real-world impact of quantum optimization.

The SoccerNet 2024 challenges represent the fourth annual video understanding challenges organized by the SoccerNet team. These challenges aim to advance research across multiple themes in football, including broadcast video understanding, field understanding, and player understanding. This year, the challenges encompass four vision-based tasks. (1) Ball Action Spotting, focusing on precisely localizing when and which soccer actions related to the ball occur, (2) Dense Video Captioning, focusing on describing the broadcast with natural language and anchored timestamps, (3) Multi-View Foul Recognition, a novel task focusing on analyzing multiple viewpoints of a potential foul incident to classify whether a foul occurred and assess its severity, (4) Game State Reconstruction, another novel task focusing on reconstructing the game state from broadcast videos onto a 2D top-view map of the field. Detailed information about the tasks, challenges, and leaderboards can be found at this https URL, with baselines and development kits available at this https URL.

Reinforcement learning (RL) has shown promise in robotics, but deploying RL on real vehicles remains challenging due to the complexity of vehicle dynamics and the mismatch between simulation and reality. Factors such as tire characteristics, road surface conditions, aerodynamic disturbances, and vehicle load make it infeasible to model real-world dynamics accurately, which hinders direct transfer of RL agents trained in simulation. In this paper, we present a framework that decouples motion planning from vehicle control through a spatial and temporal alignment strategy between a virtual vehicle and the real system. An RL agent is first trained in simulation using a kinematic bicycle model to output continuous control actions. Its behavior is then distilled into a trajectory-predicting agent that generates finite-horizon ego-vehicle trajectories, enabling synchronization between virtual and real vehicles. At deployment, a Stanley controller governs lateral dynamics, while longitudinal alignment is maintained through adaptive update mechanisms that compensate for deviations between virtual and real trajectories. We validate our approach on a real vehicle and demonstrate that the proposed alignment strategy enables robust zero-shot transfer of RL-based motion planning from simulation to reality, successfully decoupling high-level trajectory generation from low-level vehicle control.

This paper introduces SenPa-MAE, a transformer architecture that encodes the sensor parameters of an observed multispectral signal into the image embeddings. SenPa-MAE can be pre-trained on imagery of different satellites with non-matching spectral or geometrical sensor characteristics. To incorporate sensor parameters, we propose a versatile sensor parameter encoding module as well as a data augmentation strategy for the diversification of the pre-training dataset. This enables the model to effectively differentiate between various sensors and gain an understanding of sensor parameters and the correlation to the observed signal. Given the rising number of Earth observation satellite missions and the diversity in their sensor specifications, our approach paves the way towards a sensor-independent Earth observation foundation model. This opens up possibilities such as cross-sensor training and sensor-independent inference.

In this study, we evaluate the performance of current automotive communication middlewares under various operating conditions. Specifically, we examine FastDDS, a widely used open-source middleware, the newly developed Zenoh middleware, and vSomeIP, COVESAs open-source implementation of SOME/IP. Our objective is to identify the best performing middleware for specific operating conditions. To ensure accessibility, we first provide a concise overview of middleware technologies and their fundamental principles. We then introduce our testing methodology designed to systematically assess middleware performance metrics such as scaling performance, end-to-end latency, and discovery times across multiple message types, network topologies, and configurations. Finally, we compare the resulting performance data and present our results in nine findings. Our evaluation code and the resulting data will be made publicly available upon acceptance.

Recognising reinforced concrete defects (RCDs) is a crucial element for determining the structural integrity, traffic safety and durability of bridges. However, most of the existing datasets in the RCD domain are derived from a small number of bridges acquired in specific camera poses, lighting conditions and with fixed hardware. These limitations question the usability of models trained on such open-source data in real-world scenarios. We address this problem by testing such models on our "dacl1k" dataset, a highly diverse RCD dataset for multi-label classification based on building inspections including 1,474 images. Thereby, we trained the models on different combinations of open-source data (meta datasets) which were subsequently evaluated both extrinsically and intrinsically. During extrinsic evaluation, we report metrics on dacl1k and the meta datasets. The performance analysis on dacl1k shows practical usability of the meta data, where the best model shows an Exact Match Ratio of 32%. Additionally, we conduct an intrinsic evaluation by clustering the bottleneck features of the best model derived from the extrinsic evaluation in order to find out, if the model has learned distinguishing datasets or the classes (RCDs) which is the aspired goal. The dacl1k dataset and our trained models will be made publicly available, enabling researchers and practitioners to put their models to the real-world test.

Large language models (LLMs) have shown promising capabilities in healthcare analysis but face several challenges like hallucinations, parroting, and bias manifestation. These challenges are exacerbated in complex, sensitive, and low-resource domains. Therefore, in this work we introduce IC-AnnoMI, an expert-annotated motivational interviewing (MI) dataset built upon AnnoMI by generating in-context conversational dialogues leveraging LLMs, particularly ChatGPT. IC-AnnoMI employs targeted prompts accurately engineered through cues and tailored information, taking into account therapy style (empathy, reflection), contextual relevance, and false semantic change. Subsequently, the dialogues are annotated by experts, strictly adhering to the Motivational Interviewing Skills Code (MISC), focusing on both the psychological and linguistic dimensions of MI dialogues. We comprehensively evaluate the IC-AnnoMI dataset and ChatGPT's emotional reasoning ability and understanding of domain intricacies by modeling novel classification tasks employing several classical machine learning and current state-of-the-art transformer approaches. Finally, we discuss the effects of progressive prompting strategies and the impact of augmented data in mitigating the biases manifested in IC-AnnoM. Our contributions provide the MI community with not only a comprehensive dataset but also valuable insights for using LLMs in empathetic text generation for conversational therapy in supervised settings.

The successful deployment of deep learning-based techniques for autonomous systems is highly dependent on the data availability for the respective system in its deployment environment. Especially for unstructured outdoor environments, very few datasets exist for even fewer robotic platforms and scenarios. In an earlier work, we presented the German Outdoor and Offroad Dataset (GOOSE) framework along with 10000 multimodal frames from an offroad vehicle to enhance the perception capabilities in unstructured environments. In this work, we address the generalizability of the GOOSE framework. To accomplish this, we open-source the GOOSE-Ex dataset, which contains additional 5000 labeled multimodal frames from various completely different environments, recorded on a robotic excavator and a quadruped platform. We perform a comprehensive analysis of the semantic segmentation performance on different platforms and sensor modalities in unseen environments. In addition, we demonstrate how the combined datasets can be utilized for different downstream applications or competitions such as offroad navigation, object manipulation or scene completion. The dataset, its platform documentation and pre-trained state-of-the-art models for offroad perception will be made available on this https URL. \

Current architectures for multi-modality tasks such as visual question answering suffer from their high complexity. As a result, these architectures are difficult to train and require high computational resources. To address these problems we present a CLIP-based architecture that does not require any fine-tuning of the feature extractors. A simple linear classifier is used on the concatenated features of the image and text encoder. During training an auxiliary loss is added which operates on the answer types. The resulting classification is then used as an attention gate on the answer class selection. On the VizWiz 2022 Visual Question Answering Challenge we achieve 60.15 % accuracy on Task 1: Predict Answer to a Visual Question and AP score of 83.78 % on Task 2: Predict Answerability of a Visual Question.

Contrastive learning is a representational learning paradigm in which a neural network maps data elements to feature vectors. It improves the feature space by forming lots with an anchor and examples that are either positive or negative based on class similarity. Hard negative examples, which are close to the anchor in the feature space but from a different class, improve learning performance. Finding such examples of high quality efficiently in large, high-dimensional datasets is computationally challenging. In this paper, we propose a GPU-friendly Locality-Sensitive Hashing (LSH) scheme that quantizes real-valued feature vectors into binary representations for approximate nearest neighbor search. We investigate its theoretical properties and evaluate it on several datasets from textual and visual domain. Our approach achieves comparable or better performance while requiring significantly less computation than existing hard negative mining strategies.

Scientists and engineers use simulators to model empirically observed phenomena. However, tuning the parameters of a simulator to ensure its outputs match observed data presents a significant challenge. Simulation-based inference (SBI) addresses this by enabling Bayesian inference for simulators, identifying parameters that match observed data and align with prior knowledge. Unlike traditional Bayesian inference, SBI only needs access to simulations from the model and does not require evaluations of the likelihood function. In addition, SBI algorithms do not require gradients through the simulator, allow for massive parallelization of simulations, and can perform inference for different observations without further simulations or training, thereby amortizing inference. Over the past years, we have developed, maintained, and extended sbi, a PyTorch-based package that implements Bayesian SBI algorithms based on neural networks. The sbi toolkit implements a wide range of inference methods, neural network architectures, sampling methods, and diagnostic tools. In addition, it provides well-tested default settings, but also offers flexibility to fully customize every step of the simulation-based inference workflow. Taken together, the sbi toolkit enables scientists and engineers to apply state-of-the-art SBI methods to black-box simulators, opening up new possibilities for aligning simulations with empirically observed data.